Slc40a1 macrophage

Author: nzit

August undefined, 2024

WebSep 13, 2024 · By comparing human and mouse, we have recently suggested a core gene signature specific to KCs (Table 1), including CD5L, VSIG4, CD163, FOLR2, MARCO, and … WebFeb 20, 2024 · Interestingly, the levels of Slc40a1, which codes for the iron exporter ferroportin, increased during the first 24 h of treatment and decreased at 72 h (Fig. 2c ). Of note, at 24 h...

Slc40a1 solute carrier family 40 (iron-regulated …

WebFeb 9, 2024 · Quantification of monocytes and macrophages revealed that clusters CD52 mono, IRF1 mono, SERPINB2 mono, C1QC macro, and SLC40A1 macro were expanded in liver tissues and PBMCs of patients with alcoholic cirrhotic livers (P < 0.05) ( Figures 2B, E ). WebOct 31, 2024 · Of the macrophages in tumors that exhibited distinct transcriptional states, tumor-associated macrophages (TAMs) were associated with poor prognosis, and we … is dc jail public or private

Anti-SLC40A1 Antibodies Invitrogen

WebDec 28, 2024 · The glioblastoma microenvironment predominantly contains tumor-associated macrophages that support tumor growth and invasion. We investigated the relationship between tumor radiosensitivity and infiltrating M1/M2 macrophage profiles in public datasets of primary and recurrent glioblastoma. We estimated the radiosensitivity … WebApr 1, 2013 · However, SLC40A1 over expression was also reported to play a central role in macrophage antimicrobial function (Chlosta et al., 2006, Nairz et al., 2007). Macrophages isolated from flatiron mice, a strain having a heterozygous loss-of-function mutation in Slc40a1 ( Zohn et al., 2007 ), show increased susceptibility to intracellular bacterial ... WebSLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in … is dc infinite worth it

Tissue-resident macrophages provide a pro-tumorigenic niche to ... - Nature

The iron exporter ferroportin/Slc40a1 is essential for iron …

WebMar 10, 2011 · A patient heterozygous for the variant p.W158C in SLC40A1 presented with macrophage iron overload, hyperferritinemia, and normal transferrin saturation. A patient with hepatocellular iron storage, hyperferritinemia, and increased transferrin saturation was heterozygous for p.H507R. WebJan 24, 2024 · Abbreviations: RBC, red blood cells; ROS, reactive oxygen species; FPN, ferroportin (Slc40A1); HO-1, heme oxygenase-1. Heme is taken up by macrophages by … rwd stationsWebMar 29, 2024 · Single-cell RNA-seq and CITE-seq were used to profile the glioblastoma immune landscape in humans and mice, revealing the diversity and dynamics of tumor … is dc it\u0027s own state

"WebIt is known that ferroportin (SLC40A1) gene is expressed at a low level in infertile women. Its mRNA levels were discovered to be down-regulated in these women, specifically in granulosa cells. What's more, low expression of ferroportin is also associated with infertility when some features like age and smoking habits are considered. " - Slc40a1 macrophage

Slc40a1 macrophage

National Center for Biotechnology Information

WebMay 17, 2024 · A subset of macrophages expressing SLC40A1 is specifically present in para-carcinoma tissue. We identified clusters of macrophages in the UMAP plot with the … WebApr 1, 2013 · Intestinal iron absorption is mediated by SLC11A2 at the apical membrane of enterocytes, followed by basolateral exit via SLC40A1. To meet the daily requirement for iron, approximately 80% of the iron comes from the breakdown of hemoglobin following macrophage phagocytosis of senescent erythrocytes (iron recycling).

Did you know?

WebFerroportin is a 12-transmembrane domain protein, belonging to the major facilitator superfamily of transporters of small molecules, that is localized to the plasma membrane.Human Ferroportin has a theoretical molecular … WebJun 28, 2024 · Ferroportin1 ( FPN1, SLC40A1) is the only known membrane protein that transports iron out of cells 2. It is highly expressed in cells involved in iron uptake, storage …

WebApr 5, 2024 · Of the macrophages in tumors that exhibited distinct transcriptional states, tumor-associated macrophages (TAMs) were associated with poor prognosis, and we … WebMar 10, 2011 · Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin …

WebAug 13, 2024 · M2 macrophages, which resemble tumor-associated macrophages, express iron-efflux genes with increased SLC40A1 and decreased ferritin . When cultured with … WebSep 13, 2024 · First, a population of liver capsule macrophages (LCMs) have been identified ( Sierro et al., 2024 ). The liver capsule consists of a single layer of mesothelial cells and a single stratum of capsular fibroblasts existing just beneath the …

WebNatural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene. Function. This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese ...

WebJul 18, 2016 · At 16 h, a population of CD11b high F4/80 high macrophages (henceforth called transient macrophages (tMΦs)) appeared in the liver , but the number of F4/80 high CD11b int KCs was diminished. rwd small carsWebNov 21, 2024 · The presence and positive correlation of F13A1 with macrophage marker ITGAM (Integrin αM; CD11b) to F13A1 (Fig. 3E) suggests this link, but also indicates the presence of macrophages in the ... is dc in the fourth circuitWebFeb 7, 2024 · SLC40A1 solute carrier family 40 member 1. SLC40A1. solute carrier family 40 member 1. Gene ID: 30061, updated on 7-Feb-2024. Gene type: protein coding. Also … is dc legends offlineWebNov 6, 2024 · HGNC Approved Gene Symbol: SLC40A1 Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:189,560,590-189,580,786 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Cloning and Expression Defects in iron absorption and utilization lead to iron deficiency and overload disorders. rwd sunshineWebJun 16, 2024 · Tissue-resident macrophages accumulate close to tumour cells early during tumour formation to promote epithelial–mesenchymal transition and invasiveness in tumour cells, and they also induce a... is dc is stateWebSLC40A1. gene product. FPN1, HFE4, IREG1, MTP1, SLC11A3. The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal … is dc in new englandWebJan 24, 2024 · The major source of this iron is a recycling pathway where macrophages scavenge old and damaged erythrocytes to release iron contained within the heme moiety. Macrophages also promote erythropoiesis by providing a supportive niche in the bone marrow as an integral component of "erythorblastic islands." rwd stainless silverware