Lysophospholipase d
WebAlthough several metabolic routes have been reported for intracellular formation of LPA, a unique route involving lysophospholipase D, an extracellular enzyme that produces … Web1 ian. 2024 · Autotaxin (ATX) is a lysophospholipase D (lyso-PLD)-type exoenzyme that is secreted into the plasma and functions as a key enzyme that produces extracellular LPA from lysophosphatidylcholine (LPC) ( 9 ), and its activity is stimulated by divalent cations, including Mg 2+ and Ca 2+ ( 10 ).
Lysophospholipase d
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WebLysophospholipase D (lysoPLD), generating lipid mediator lysophosphatidic acid (LPA) from lysophosphatidyclcholine (LPC), is known to be inhibited by lysophosphatidic acids. Meanwhile, some plant lipids are known to contain lysophospholipids as minor components. Web11 apr. 2024 · Autotaxin (ATX), the key enzyme that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), is involved in tumorigenesis through the ATX-LPA axis and is regarded as a valuable target in tumor therapy. Hypoxia is a major feature of solid tumors and contributes to tumor development with striking alterations in the gene …
Web18 oct. 2002 · We purified human plasma lysophospholipase D that produces physiologically active lysophosphatidic acid and showed that it is a soluble form of … WebA major source of extracellular LPA is cleavage of lysophospholipids, predominantly lysophosphatidylcholine (LPC), by a lysophospholipase D named autotaxin (ATX). LPA …
Web24 dec. 2024 · Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 2002; 158: 227-233. Google Scholar). Thereafter, ENPP6 was characterized as a choline-specific phospholipase C (PLC) and ENPP7 as an alkaline sphingomyelinase that converts membrane sphingomyelin … Web18 oct. 2002 · We purified human plasma lysophospholipase D that produces physiologically active lysophosphatidic acid and showed that it is a soluble form of autotaxin, an ecto-nucleotide pyrophosphatase/phosphodiesterase, originally found as a tumor cell motility-stimulating factor.
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Web21 mar. 2024 · ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with ENPP2 include Autoimmune Pancreatitis and Teratocarcinoma . Among its related pathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism . python http 308WebQ8N9F7 - GDPD1 - Lysophospholipase D GDPD1 - Function. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550, PubMed:25596343). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and … python hsv 추출Strictly speaking, phospholipase D is a transphosphatidylase: it mediates the exchange of polar headgroups covalently attached to membrane-bound lipids. Utilizing water as a nucleophile, this enzyme catalyzes the cleavage of the phosphodiester bond in structural phospholipids such as phosphatidylcholine and phosphatidylethanolamine. The products of this hydrolysis are the membrane-b… python html auslesenWebPhospholipase Ds (PLDs) are multifunctional and disease-relevant enzymes operating at the center of phospholipid metabolism and signaling. Physiologically, they hydrolyze abundant phospholipids into phosphatidic acid (PA), a potent lipid second messenger and central biosynthetic intermediate. python html to jsonWeb21 mar. 2024 · LYPLA1 (Lysophospholipase 1) is a Protein Coding gene. Among its related pathways are RAF/MAP kinase cascade and Metabolism of nitric oxide: NOS3 … python html 转 jpgWebAutotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX … python html 開くWeb3 oct. 2006 · Lysophospholipase D activity is increased by magnesium and manganese and inhibited by calcium in a concentration dependent manner ( PubMed: 27637550 ). … python html link