Heparan sulfate proteoglycan core protein
WebWe have isolated a cDNA coding for the core protein of the large basement membrane heparan sulfate proteoglycan (HSPG) from a human fibrosarcoma cell (HT1080) … Modifications of the heparan sulfate chains on C- and N-terminal domains are the best-studied differences in the secretory pathway of perlecan. Chondroitin sulfate can be substituted for heparan sulfate, and sulfate incorporation or the sugar composition of the chains can change. Loss of enzymes involved in the heparan sulfate synthetic pathway lead to a number of conditions.
Heparan sulfate proteoglycan core protein
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Web25 mei 1990 · The extracellular matrix of cultured human lung fibroblasts contains one major heparan sulfate proteoglycan. This proteoglycan contains a 400-kDa core protein … WebThe heparan sulfate proteoglycan (HSPG) family of cell-surface proteins is emerging as a key regulator of connectivity. HSPGs are expressed throughout brain development and …
Web1 jun. 2007 · Proteoglycans consist of a core protein carrying long unbranched disaccharide chains. Different types of chain are distinguished by the nature of the … Web24 feb. 2024 · Since syndecan-1 is the dominant, if not the only, heparan sulfate proteoglycan expressed on MM cells, the data would indicate that these antibodies also …
WebProteoglycans (PG) are complex macromolecules which consist structurally of a core protein and associated glycosaminoglycan (GAG) chains. The different GAG chains of … WebTo examine whether the sulphation state of the attached heparan sulphate glycosaminoglycans was dependent on the protein core, we purified syndecan-1 from …
Web1 jan. 2001 · Domain structure of the basement membrane heparan sulfate proteoglycan. Biochemistry. 1987 Feb 24; 26 (4):988–995. [Google Scholar] Marynen P, Zhang J, …
WebHeparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have … eco power innovations reviewsWeb21 mrt. 2024 · HSPG2 (Heparan Sulfate Proteoglycan 2) is a Protein Coding gene. Diseases associated with HSPG2 include Schwartz-Jampel Syndrome, Type 1 and … concept 2 rower black model dWeb14 sep. 2024 · Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are … eco power innovations ltdWeb4 apr. 2024 · HSPG2 heparan sulfate proteoglycan 2 [ (human)] Gene ID: 3339, updated on 5-Jan-2024 This gene encodes the perlecan protein, which consists of a core … ecopower houtbrikettenWebHeparan sulfate proteoglycans (HSPGs) are cell-surface and extracellular matrix (ECM) macromolecules that comprise a core protein to which heparan sulfate (HS) … concept 2 rower chain replacementWeb4 okt. 2024 · The perlecan proteoglycan has a core protein of 400,000 MW containing three heparan sulfate chains of 65,000 MW each (Snow and Wight, 1989). Heparan … concept 2 rower batteryWebThe basic proteoglycan unit consists of a "core protein " with one or more covalently attached glycosaminoglycan (GAG) chain (s). [2] The point of attachment is a serine … eco power hull