Cral-trio lipid binding domain

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August undefined, 2024

WebNov 1, 2024 · CRAL_TRIO family proteins are cytosolic and contain the SEC14 carboxy-terminal domain [7,9]. The CRAL_TRIO subgroup derives its name from the cellular retinaldehyde-binding protein (CRALBP) and the TRIO guanine exchange factor [11]. SEC14 was originally shown to be a cytosolic factor that promotes protein export from … WebSeveral CRAL-TRIO domain proteins have been shown to bind phospholipids in addition to their hydrophobic ligand (27,28), prompting us to test whether the CPSFL1 protein is capable of binding ...

ZFIN Gene: atcaya - Zebrafish Information Network

WebMay 15, 2010 · The activation of the protein kinase Raf at the cell membrane is a critical step in cell signaling during development, but the mechanisms that regulate Raf activity remain incompletely defined. We previously demonstrated that the C. elegans cgr-1 gene encodes a CRAL/TRIO domain-containing protein that is a critical modulator of Ras … WebThe bipartite CRAL_TRIO motif is composed of a large lobe encoding a hydrophobic lipid-binding pocket (CRAL_TRIO_C) that is closed off by a smaller N-terminal lobe (CRAL_TRIO_N) . To analyze the lipid-binding activity of CPSFL1, we used recombinant affinity-purified Sec14 proteins and performed protein−lipid blot overlay assays (Fig. 5A, … scary games for free to play

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WebJul 1, 2015 · The CRAL_TRIO domain is an N-terminal ligand binding region within a larger protein domain (SEC14) that takes its name from common sequence elements in cellular retinaldehyde binding protein (CRALBP) and the signaling domain of the TRIO guanine exchange factor (Panagabko et al., 2003). ... The SEC14 domain contains a … WebAug 23, 2024 · The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. [3] Structure. The Sec14 protein was the first CRAL-TRIO domain for which the structure was determined. [4] The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and … WebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. CRALB proptein carries 11-cis-retinol or 11-cis-retinaldehyde. It is a carrier that modulates interaction of retinoids with visual cycle enzymes. scary games for free on steam

Gene Expression of CRAL_TRIO Family Proteins …

A gold revision of the Golgi Dynamics (GOLD) domain structure …

WebMay 15, 2010 · CRAL/TRIO domains form hydrophobic binding pockets that bind small hydrophobic ligands (Bateman et al., 2000, Sha et al., 1998, ... Finally, TAP-1 may have lipid exchange activity as proposed for other CRAL/TRIO domain proteins (Phillips et al., 1999). In this case TAP-1 may regulate the lipid environment at the cell membrane, … WebSuperfamily assignments for Oryza sativa ssp. Indica . Summary assignment statistics followed by sortable table of detailed assignments with number of domains, proteins and families assigned for each superfamily. scary games for free online playWebThe Sec14 domain is depicted in yellow with N-terminal CRAL-TRIO domain as an oval structure. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] from ... scary games for laptop free

"WebMay 1, 2013 · CRAL-TRIO lipid binding domain; Ligands and Environments 2 bound ligands: 4 x VIV. 4 x 3PT. No modified residues. Experiments and Validation Details. X-ray source: MACSCIENCE. Spacegroup: P1. Unit cell: a: 58.285Å b: 69.665Å c: 87.183Å α ... " - Cral-trio lipid binding domain

Cral-trio lipid binding domain

ZFIN Gene: bnipl - Zebrafish Information Network

WebSep 1, 2009 · ProNGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). By similarity. ... 3.40.525.10 CRAL-TRIO lipid binding domain 1 hit; 1.20.900.10 Dbl homology (DH) domain 2 hits; ... SSF52087 CRAL/TRIO domain 1 hit; SSF48065 DBL homology domain (DH-domain) 2 hits; WebAug 1, 2008 · • Proteins containing the lipid-binding Sec14 domain, also referred to as the CRAL-TRIO domain, ar e found throughout eukaryotic organisms ranging from yeast to humans.

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WebSpecific lipid-binding protein domains, such as PH, FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions between proteins and specific phospholipids. Here we review the published literature, plus some of our most recent unpublished findings, regarding the biology of the SEC14 domain, also known as CRAL_TRIO domain. WebCRAL-TRIO lipid binding domain superfamily CRAL/TRIO, N-terminal domain CRAL/TRIO, N-terminal domain superfamily; UniProtKB:Q7SXG2. InterPro 118: UniProtKB:A0A0R4ITM7. InterPro 118: UniProtKB:B0S5J5. InterPro 285: Transcripts ...

WebDec 1, 2024 · Many lipid transfer proteins remain unstudied, even those that have an essential function, including PF3D7_0920700, a predicted Sec14/CRAL/TRIO phospholipid transfer protein, and PF3D7_1324400, a PRELI domain-containing protein predicted to be involved in phospholipid and phosphatidic acid transport (Table 1). WebApr 21, 2024 · Important regulators of PI phosphorylation and distribution are proteins harboring a CRAL_TRIO (cellular retinaldehyde binding-triple response) domain, for which yeast Sec14 is the prototype (2, 3). Sec14-like proteins bind PI in a hydrophobic cavity in the CRAL_TRIO domain. In that cavity, another hydrophobic ligand can be bound alternatively.

WebCRAL-TRIO lipid binding domain superfamily PH-like domain superfamily Ras GTPase-activating domain Ras GTPase-activating protein Ras GTPase-activating protein, conserved site Rho GTPase activation protein; UniProtKB:E7FFY1. InterPro 2759: Transcripts Genome Browsers ... WebNov 1, 2024 · The homologous domain within SEC14 proteins is believed to be essential to lipid binding, but multi-domain proteins containing a SEC14 domain may be involved in more complex processes including transport and signal transduction related to lipid metabolism [13]. A subgroup of the SEC14/CRAL_TRIO family is known as SEC14L.

WebCRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily; UniProtKB:A8DZD4. InterPro 361: Transcripts . Genome Browsers. UCSC NCBI Ensembl ZFIN. Type Name Length (nt) Analysis ; mRNA: bnipl-201 Ensembl. 1400 nt: Select Tool ZFIN BLAST NCBI BLAST Ensembl ...

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 scary games for laptop rum barrel coffeeWebThe lipid binding cavity is shown in grey, the CRAL/TRIO_N domain in navy, the Sec14 domain in turquoise-green, and the GOLD domain in yellow-orange (as on the scheme in Fig. 1.2). Taken from ... scary games for kids for freeWebMay 10, 2016 · The deduced 354-amino acid protein contains a conserved CRAL-TRIO domain (residues 118-279) that is 45% identical to that in cellular retinaldehyde-binding protein (CRALBP, or RLBP1; 180090). The CRAL-TRIO domain is present in members of the lipid-binding SEC14-like proteins. RT-PCR analysis of 18 human tissues showed … scary games for little kidsWebThe CRAL-TRIO domain is a structurally conserved element of about 170 amino acids, which constitute a hydrophobic lipid binding pocket. The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and ... scary games for pc multiplayerWebSep 11, 2024 · While the SEC14 domain and its CRAL-TRIO-N-terminal extension serve general membrane attachment of the protein, the C-terminal GOLD domain directs it to the plasma membrane by recognizing specific phosphoinositides. ... Saito K, Tautz L, Mustelin T (2007a) The lipid-binding SEC14 domain. Biochim Biophys Acta 1771:719–726. CAS … scary games for kids at sleepoversWebIt engages lipid droplets via its CRAL-TRIO domain, which specifically recognizes packing defects and negatively charged phospholipids . This module is also referred to as the SEC14 domain, and is known to bind PI lipids [ 124 , 125 ]. rum bar sheffield