WebApr 14, 2024 · Among the changes potentially relevant are the differences in the content of pyridoxine and kynurenine between the two types of ABs, i.e., cisplatin-treated vs. UV light exposed-cells, both in ABs content ( Table 1 and Figure S1) and in the extracellular fluid ( Table 1 and Figure S2 ). WebJan 1, 2024 · Cisplatin treatment induces premature senescence in renal tubular cells in vitro and in vivo To evaluate whether cisplatin can induce senescence in renal tubular cells in vitro, NRK cells were incubated with cisplatin (20 μg/ml) for 6 h, and then incubated in complete medium for 24, 48, and 72 h.
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WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... WebMar 29, 2024 · A study involving TLR4-deficient mice administered a toxic dose of cisplatin (20 mg/kg) to induce acute renal failure within 72 h and reported significantly reduced markers of inflammation, nephrotoxicity, and renal function and decreased renal injury and histological abnormalities . no right click editing
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WebDec 12, 2024 · Cisplatin is mainly excreted through the kidneys and can induce nephrotoxicity through proximal tubular injury, by promoting oxidative stress via reactive oxygen species (ROS), inflammation, apoptosis, autophagy and vascular injury in … WebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment.Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy. WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and … no right click on mouse