Cisplatin and kidney damage
WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …
Cisplatin and kidney damage
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WebCisplatin and kidney damage Kent Cass Member Posts: 1,898 Member January 2010 edited March 2014 #1 The subject of kidney damage as a result of chemo by Cisplatin … WebOct 22, 2024 · As repeated injections of 6 mg/kg cisplatin in a one-week interval did not cause apparent kidney injury and those of 10 mg/kg cisplatin accelerated kidney injury without causing lethality,...
WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including DNA damage,... Multiple stress responses, including … WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignanc Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome Federal Practitioner
WebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also activates apoptotic pathways and inflicts cellular damage via oxidative stress and inflammation. One of its dose limiting toxicities is its effects on the kidney. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …
WebKidney damage after Cisplatin buzz99 Member Posts: 404 May 2011 #1 Has anyone had kidney damage after Cisplatin? Buzz has elevated Creatinine, BUN, and decreased …
WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … inch kochel ays sere 127WebAug 6, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. inch kochel ays sere 126WebMar 9, 2024 · Cisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher … inaktivera windows 10 sWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … inaktivera touch windows 10WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has … inaktivera touch screenWebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause... inch kochel ays sere 139WebMay 8, 2024 · Serum Creatinine (SCr)-Acute Kidney Injury (AKI) Staging Outlined by the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines and Electrolyte-AKI (eAKI) Grading Based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4 eTable 2. inch kochel ays sere 122